Increasing time intervals between meals makes male mice more healthy and they live longer than mice that eat more often. This is evidenced by a new study published in the new issue of the journal Cell Metabolism on 6 September 2018. American scientists from the National Institute on aging (NIA, National Institute on Aging), National institutes of health (National Institutes of Health), together with colleagues from other scientific organizations, reported that the health of the mice improved, and their life span increased with increasing time intervals between meals, regardless of what the mouse ate or how many calories they consumed.
The study showed that mice who ate once a day and who have therefore had the longest period of fasting, live longer and are more resistant to common age-related diseases of the liver and metabolic disorders. The results of animal studies show that it is necessary to carefully consider the interaction of caloric intake, and periods of feeding and fasting, says NIA Director Richard J. The Hodes (Richard J. Hodes).
292 the researchers divided male mice into two groups who were given food in different modes. One group received natural food containing a smaller amount of purified sugar and fats and more proteins and fiber. Mice in each group then divided into three subgroups on the basis of how often they have access to food. The first group of mice had access to food around the clock. The second group of mice were given 30% fewer calories in a day than the first group. The third group was fed only once a day, but gave much calories as the first group. Mice from the second and third groups quickly learned to eat until food was available, with the result that they have increased the period of fasting between meals.
Scientists have tracked the metabolic health of mice, and then examined them after death. Mice from the second and third groups showed improvement in General health status, as evidenced by the delay of age-related damage to the liver and other organs, as well as the relatively long life expectancy. Mice from the second group also showed a significant improvement in the level of blood glucose and insulin levels fasting compared to other groups.
Interestingly, the researchers found that the composition of the diet has no significant effect on life expectancy in the second and third groups. According to lead author of the study, Rafael de Cabo (Rafael de Cabo), more than a hundred years scientists have studied the beneficial effects of calorie restriction, but the influence of increasing periods of starvation only now began to scrutinize.
Increase the daily periods of starvation without reducing the number of calories and regardless of the type of consumed diet has led to overall improvements in health and longevity in mice-males. Perhaps a greater daily period of fasting allows you to use certain mechanisms of health maintenance and recovery, which would be absent with constant access to food, said de Cabo.
The researchers argue that their results provide impetus for further studies to clarify the options to limit power on time will be able to help people maintain a healthy weight and reduce some General age-related metabolic disorders.