Three people died of breast cancer after they all caught it from the SAME organ donor, ‘extraordinary’ report reveals
- The donor was a 53-year-old woman who died of a stroke in 2007
- She donated her kidneys, lungs, liver and heart but four of five recipients died
- Four of them all developed breast cancer from their new organs
- Doctors had not noticed the disease in tests on the donor after she died
- Experts say there is a 1 in 10,000 chance of getting cancer from an organ donor
Three people died after the same organ donor gave them all breast cancer, an ‘extraordinary’ case report has revealed.
The donor, a 53-year-old woman, died of a stroke in 2007 and donated her kidneys, lungs, liver and heart to patients needing transplants.
But within six years of the woman’s organs being transplanted, four of the five recipients had died as a result.
The heart patient died of sepsis but the other four developed breast cancer which spread into their healthy organs. Only one survived.
The cancer was not noticed by doctors before the woman’s organs were donated and they acted as Trojan horses, secretly carrying the disease into the patients’ bodies.
Experts say the odds of getting cancer from any single organ transplant could be as small as one in 10,000.
And they believe this is the first time one patient has passed cancer on to four recipients, and it has never been seen to take so long for tumours to develop.
Only one out of five people who recieved organs from the same woman survived more than six years, after one died soon after of sepsis and three others were killed by breast cancer which had gone undetected until it spread into recipients’ healthy organs
Research by scientists at University of Tübingen in Germany and the VU University Medical Center in the Amsterdam, the Netherlands, revealed the strange tragedy which unfolded during six years after the donor died.
The experts insist donor screenings do work well enough and say there is a 0.01 to 0.05 per cent chance of getting cancer from any donated organ.
The first person to be diagnosed in the peculiar case was a 42-year-old woman who received both the donor’s lungs.
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Less than a year-and-a-half after receiving her new lungs, the woman was admitted to hospital because they weren’t working properly.
Doctors then discovered she had breast cancer which had started in her lungs and spread to her bones – it later spread to her liver and she died in August 2009.
The disease is still called breast cancer even when elsewhere in the body because the tumours are made of cells specific to the original cancer which started in breast tissue but have spread.
Medics proved the cancer had originated in the organ donor by doing DNA testing.
When news got out about the lung transplant recipient dying, the 62-year-old woman who recieved the left kidney and the 32-year-old man who received the right kidney were both warned about the risk of cancer.
Tests were done on both but no sign of the disease was found right away.
But in 2011 the man was diagnosed with cancer in his kidney, and the woman was found to have cancer in her liver, but not until five years later.
GROWING NUMBER OF PATIENTS WAITING FOR LUNG TRANSPLANTS
The number of people in the UK who are waiting for a lung transplant has risen by nearly half in the past five years.
Some 354 people in the UK now need a new lung in order to survive, compared to 242 people in 2013 – a rise of 46 per cent.
And around a quarter of patients on the list will die before they get a new lung, or become so frail they can no longer have a transplant.
NHS Blood and Transplant said people on the organ donor list are getting older and less healthy so their lungs aren’t suitable for transplants.
John Forsythe, NHS Blood and Transplant’s associate medical director said: ‘Last year, 65 people died on the lung transplant waiting list and many of those lives could have been saved or transformed had more families said yes to donation.
‘Sadly, many donation opportunities are lost every year because families don’t know if their loved one wanted to be a donor or not.
‘We urgently need people to tell their families they want to donate.’
The man had his transplanted kidney removed and took chemotherapy drugs for a year, and has been cancer free since 2012.
However, the woman’s cancer, which was first noticed in her liver, then appeared in her kidney, bones, spleen and other organs in the digestive tract.
Her treatment was withdrawn and she died two months after being diagnosed – a full six years after first receiving the donor kidney.
The fourth patient to get cancer from the transplanted organs was a 59-year-old woman who recieved the liver, to replace hers which was damaged by cirrhosis.
Her tumour was detected in 2011 but she refused to have the liver removed, fearing similar complications to the ones she experience after the first op in 2007.
Researchers said ‘she felt well’ and treatment managed to stabilise the disease. But when the cancer began to spread in 2014, she refused any further treatment and died.
The scientists suggest keeping the organs warm without a blood supply could have allowed tumour cells which were moving in the bloodstream to settle in the organs and begin to spread.
And because the patients were taking drugs to weaken their immune systems to stop their bodies rejecting the organs, the cancer could have been able to grow unchecked.
But, they said, scanning donors too intensively could bring up minor problems leading to more desperately-needed donors being rejected.
The authors, led by Yvette Matser, wrote: ‘The drawback of a routine postmortem CT scan for all donors is that it will increase clinically irrelevant findings, which might lead to more rejection of donors and a decrease of the already scarce donor pool.
‘The extremely low rate of transmission of malignancies during transplantation proves the efficiency of the current guidelines.
‘A complete medical examination, including a breast examination, should always be performed as described in the guidelines of the Organ Procurement and Transplantation Network.’
They added: ‘This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.’
The findings were published in the American Journal of Transplantation.
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