Vaccination against high cholesterol levels

The same three studies with a new drug against too much LDL cholesterol in the blood are to come, promising results. Particularly, the administration: It is injected like a vaccination only every six months under the skin and lowers the level of cholesterol in the long term by about half.

The active ingredient "Inclisiran" is injected under the skin and then lowers for many months the level of cholesterol: In patients with a familial-related elevated cholesterol levels, the &quot was;schlechte" LDL-cholesterol of 17 months after the start of treatment to 39.7 percent lower than before, while it was increased in the control group, in which participants had only received a Placebo, 8.2 percent. The difference between the two groups amounted to almost 48 percent. The drug was very well tolerated, and could also be used in combination with a cholesterol-lowering Statin-lowering administered.

In another study, patients were treated, had, in spite of maximal Statin therapy, high cholesterol. You, too, as it came within 17 months, a significant reduction in the values as compared to Placebo, to 52.3 percent. Overall, a stable reduction of cholesterol to about half of its original value between the third and eighteenth month, was shown in the studies. Thus, the frequency decreased serious cardiovascular diseases.

It has already been submitted to the competent authorities an application for market approval, and is currently being tested in further long-term studies, such as the new drug diseases, long-term monitoring and the mortality effect.


Sources: DOI 10.1056/NEJMoa1913805 DOI 10.1056/NEJMoa1912387

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