Forecast of type 2 Diabetes improved before?
Special metabolites in the blood indicate whether or not a woman will develop after a temporary pregnancy go diabetes to type 2 Diabetes. On the Basis of this knowledge could be developed in the future, a Test which women identified with increased risk.
In the case of a current investigation under the direction of researchers at the University of Toronto was found that metabolites of clues in the blood, whether or not a woman will develop after pregnancy type 2 Diabetes. The results of the study have now been published in the English journal “PLOS Medicine”.
How often gestational diabetes occurs?
Approximately every tenth woman develops during pregnancy gestational diabetes, which exposes them to a higher risk for type 2 Diabetes. Approximately 30 to 50 percent of these women fall ill then, within ten years after the birth of type 2 Diabetes.
A complication of gestational diabetes
Gestational diabetes hinders the body’s ability to regulate blood sugar levels. The disease can lead to serious complications such as vision loss, neurological problems and heart and kidney diseases.
What should women with gestational care diabetes?
Women with gestational diabetes it is recommended that after the birth of a yearly oral glucose tolerance test, which measures the ability of the body to remove sugar from the bloodstream. However, the procedure is time and labor consuming and is only performed by less than half of the women.
Why a new Test is needed
When women have a newborn baby at home, don’t you think easy often to their own health or they simply have no time for this. The goal of the research team was therefore to develop a simple blood test that can tell the risk of Diabetes in advance, report the researchers.
Predictive metabolic signatures identified
In 2016, carried out a pilot study on a total of 1,033 women with gestational diabetes identified the research-based metabolic signatures, which are used for type-2 Diabetes, predictive, for the first time. The current study builds on previous research, and followed the same cohort of women over a longer period of time.
In the course of the study, several blood samples were taken
The initial blood samples were taken between six and nine weeks after birth and then twice within two years. The health of the women was followed on the basis of their electronic medical records up to eight years. During this period, 173 women with type 2 Diabetes developed. Their blood samples with those of 485 healthy women compared, which also took part in the study.
Metabolic Dysregulation indicates later problems
In the group of women who will develop the disease in the early postpartum period in type 2 Diabetes, there is a so-called metabolic Dysregulation, suggesting that an underlying Problem exists, which can be identified, explain the researchers.
Prediction with accuracy of more than 85 percent
The investigation identified a metabolic signature and can say with about 85% accuracy predict whether a woman with type 2 Diabetes will develop emphasizes the research group.
What suggest that amino acids and lipid molecules?
It is not surprising that sugar molecules play among the Compounds identified, a prominent role, report the researchers. There’s also amino acids and lipid molecules were present, this indicates fundamental problems in Protein and towards fat metabolism.
In fact, the predictive power of the Tests decreased when amino acids and lipids were excluded. This suggests that processes that go beyond the glucose metabolism may occur very early in the development of the disease. The result could explain why complications in people with type 2 Diabetes to occur even if the blood sugar with medication is strictly controlled.
New blood test in views?
The researchers hope to develop on the basis of the new knowledge a simple blood test that can be carried out early after the birth. In the study, participating women will be a 10-year Follow-up visit to invited you to a type-2-Diabetes will be tested. The information obtained will drive the development of a new blood test even further, report the researchers. (as)