Adipose tissue, commonly called “body fat,” stores excess fatty acids and supplies it back when the need arises. Finely balanced iron levels are important for the health of adipocytes, the cells that make up adipose tissue. Iron overload, especially in adipocytes, can reduce systemic insulin sensitivity.
Immune cells called macrophages are the primary cells responsible for handling iron in the body.
A macrophage in adipose tissue called the MFehi adipose tissue macrophage (ATM) was previously discovered in the lab of Alyssa Hasty, Ph.D. It contains twice the iron as other ATMs and exhibits higher expression of iron-handling genes.
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