- 12% of heart attacks, stroke, revascularization procedures, death from cardiovascular causes and hospitalization or emergency room visit for heart failure;
- 39% of deaths from cardiovascular causes; and
- 21% of deaths from any cause.
- There was no significant difference in serious adverse events of low blood pressure, electrolyte abnormality, fall resulting in an injury, acute kidney injury or renal failure.
- The ESPRIT trial included 11,255 adults in China. Participants had a baseline systolic blood pressure measurement of 130-180 mm Hg and either established cardiovascular disease or at least two major risk factors for cardiovascular disease.
- Participants were an average age of 64.6 years; 41.3% were identified as women and 58.7% were identified as men, according to their national ID cards.
- Approximately 27% of the study participants had a history of stroke; approximately 29% had previous coronary heart disease; and approximately 39% had diabetes, type 1 or type 2.
- The trial’s primary outcome was a composite outcome of heart attack, coronary or non-coronary revascularization, hospitalization/emergency room visit for heart failure, stroke or CV death. Secondary outcomes included CV outcomes, kidney outcomes, and cognitive outcomes.
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