Among the antianxiety drugs is considered to be one of the most popular Adaptol (Mebicar). The drug has a mild anti-anxiety and tranquilizing effect, helping to eliminate fear and anxiety. I created this drug, and whether it is proved its effectiveness?
- ANTIBIOTIC: HELP
- A BIT OF HISTORY
- HOW DOES THE DRUG
- EVIDENCE BASE: THE FLY IN THE OINTMENT
- OVERDOSE AND SIDE EFFECTS
Antibiotic: help
Adaptol (mebicar) antianxiety drug, active substance of which is тетраметилтетраазабициклооктандион.
Adaptol has a moderate tranquilizing (anxiolytic) activity, eliminates or reduces anxiety, anxiety, fear, internal emotional tension and irritation. The soothing effect of the drug is not accompanied by muscle relaxation and loss of coordination. The drug reduces the mental and physical activity, therefore Adaptol can be used in the course of the working day or during training. The drug does not create elevated moods, feelings of euphoria. On this basis, Adaptol relate to daytime tranquilizers. Sleeping pill has no effect, but enhances the effect of hypnotics and improves sleep at his violation.
A bit of history
The drug mebicar was created in the Laboratory of nitrogen-containing compounds in the Institute of organic chemistry named after Zelinsky. Tranquilizing effect of the drug has identified an employee of the Department of pharmacology of Kazan state medical University Irina zimakova. Academic for a long time engaged in the study of poliittisten heterocyclic compounds and urea derivatives.
The synthesized drug was called mebicar, after which it presented in the Pharmacological Committee of the Ministry of health of the USSR for a special permit to conduct the clinical research that was obtained. Already in 1978 mebicar was approved for widespread clinical use by the order of Ministry of health of the USSR.
How does the drug
In the instruction it is specified that mebicar acting on the structure included in the limbic-reticular complex. In particular, we are talking about areas of the hypothalamus responsible for the expression of human emotions. In addition, the drug has an effect on all four neurotransmitter systems (GABA-, serotonin-, choline – and adrenergic).
Clinical studies conducted in the USSR and Russia, show that the drug has nootropic action. Mebicar improves the level of logical thinking, speed, and coherence of thinking and enhances mental performance of a person and concentration.
Based on the properties of the drug currently used in the following diseases and conditions:
- emotional anxiety;
- anxiety;
- fear;
- anxiety-delusional state;
- hypomanic state;
- withdrawal syndrome (it is used in treatment);
- other States (read instruction or by the physician).
Evidence base: the fly in the ointment
This drug is not so simple as would like. Let’s start with the fact that it has not been registered in the FDA, the Federal Agency on control over foodstuff and medicines of the USA. We cross-checked this information (perhaps it was registered recently), but in the list of approved drugs mebicar does not appear.
However, note that the FDA does not figure, because the drug (even if it really is effective) may simply not register in the US for various reasons. By the way, the procedure of approval of the drug in the United States through this organization is an incredibly complex process. FDA experts are studying millions of pages of research, analyze the data, and only after the Commission makes a decision on the drug. And do these same studies on the drug to the same the FDA had something to learn.
Go to Pubmed and see that the request Tetramethyltetraazabicyclooctandione only one study Dating back to 2018! Nonsense! For example, if you search information in the same database alprazolam (the active ingredient Xanax), then the system will give you 2559 scientific articles! However, if the search engine Pubmed to enter the word mebicar, the system issues 67 articles, among which almost all were published in Russian scientific journals. This amazing case is when the title of a scientific article is used not the name of the existing drug. On request adaptol the system will give you 70 scientific publications. It is extremely small for a drug with proven clinical efficacy, moreover, that all scientific publications are Russian.
Important!
You can identify drugs registered in the FDA. To do this, go to the website of the organization where the search drug name or active substance. The chemical name of the system you will be given a list of all registered and approved products containing this substance.
Overdose and side effects
The chemical structure of mebicar in its formula resembles natural metabolites in the body, so the drug has low toxicity. In case of overdose, the likelihood of serious violations is low, but may cause allergic reactions, digestive disorders, the appearance of weakness and a temporary drop in blood pressure. Therefore, people with low blood pressure should be alert.
Side effects from taking normal doses of these occur very rarely. Pregnant women take the drug not because mebicar penetrates into all body fluids, and clinical data on the safety of drug in pregnancy and lactation yet.
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